Atypical Antipsychotics

General side effects:

tardive psychosis, acute dystonias, akathisia, parkinsonism (rigidity and tremor), tardive dyskinesia, tachycardia, hypotension, impotence, lethargy, seizures, intense dreams or nightmares, and hyperprolactinemia.

Sedation

Clozapine > zyprexa, seroquel, geodon > abilify, risperdal

Weight Gain

Clozapine, zyprexa > seroquel > risperdal > geodon, abilify

Hypotension

Clozapine > zyprexa, seroquel, risperdal > geodon, abilify

QT interval changes

Seroquel > geodon > zyprexa > risperdal > abilify (clozapine N/A)

Parkinsonism

Risperdal > zyprexa > seroquel > clozapine, geodon, abilify

Akathisia

Risperdal, zyprexa, clozapine, abilify > Seroquel, geodon

Hyperprolactinemia

Risperdal > zyprexa, geodon > abilify, clozapine, seroquel

Other Side Effect

Clozapine – agranulocytosis, seizure

Abilify – headache, anxiety, insomnia

Zyprexa – weight gain, hyperglycemia, diabetic ketoacidosis

Seroquel – orthostasis, sedation

Risperdal - orthostasis, tachycardia, nasal congestion

Geodon - QT prolongation (contraindicated in cardiac patients and those with recent MI)